Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo
نویسندگان
چکیده
منابع مشابه
Stem cells and tissue-engineered skin.
Advances in tissue engineering of skin are needed for clinical applications (as in wound healing and gene therapy) for cutaneous and systemic diseases. In this paper we review the use of epidermal stem cells as a source of cells to improve tissue-engineered skin. We discuss the importance and limitations of epidermal stem cell isolation using biomarkers, in quest of a pure stem cell preparation...
متن کاملTissue Engineered Human Skin Equivalents
Human skin not only serves as an important barrier against the penetration of exogenous substances into the body, but also provides a potential avenue for the transport of functional active drugs/reagents/ingredients into the skin (topical delivery) and/or the body (transdermal delivery). In the past three decades, research and development in human skin equivalents have advanced in parallel wit...
متن کاملBilayer hydrogel with autologous stem cells derived from debrided human burn skin for improved skin regeneration.
The objective of this study was to demonstrate that stem cells isolated from discarded skin obtained after debridement can be used with collagen and fibrin-based scaffolds to develop a tissue-engineered vascularized dermal equivalent. Discarded tissue samples were collected from severely burned patients undergoing wound debridement. Stem cells were isolated from the adipose tissue layer and the...
متن کاملSkin in vivo Dosimetry in Radiotherapy
Introduction: Due to the prevalence of skin problems in patients after radiotherapy, skin dose measuring is importance. Content: Skin in vivo dosimetry means measuring the patient's (or phantom) skin dose during radiotherapy. According to the ICRP 59, the dose at the depth of 0.07 mm is known as a skin dose. The most radiosensitive epidermis cells are located...
متن کاملExperimental study on repairing skin defect by tissue-engineered skin substitute compositely constructed by adipose-derived stem cells and fibrin gel.
OBJECTIVE To study the application value of artificial skin substitute compositely constructed by adipose-derived stem cells and fibrin gel in skin defect. MATERIALS AND METHODS Adipose-derived stem cells (ADSCs) were obtained from healthy pure green fluorescent protein (GFP) transgenic mice and were proved to have multiple differentiation potentials. They compositely constructed artificial s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Stem Cell Research & Therapy
سال: 2020
ISSN: 1757-6512
DOI: 10.1186/s13287-020-01924-z